Bone Skewer
Can units with "I can't be chosen by enemy spells and abilities." be chosen with Bone Skewer?
Yes.
Passive abilities of permanents are only active while on the board,[365.1] so that protection — as seen on units like Ruin Runner and Baron Nashor — has no effect while the unit is in the opponent's hand. Beyond that, Bone Skewer never targets the chosen unit in the first place — cards in hand are never targets because the hand is not a public zone,[355.10.a] so there is no finalization step at which a unit there could be declared as a target.[355.5]
Can the opponent trigger an optional additional cost effect when playing a unit via Bone Skewer, even though its costs are ignored?
Yes.
Bone Skewer reduces all costs to 0, but the opponent may still declare their intention to pay an optional additional cost. Discounts can reduce additional costs all the way to 0,[356.4.f] so when a game effect has already done so, that declaration is sufficient — an optional additional cost is considered paid based on the decision to pay, not the amount actually spent.[356.4.f.1] Any conditional effect tied to "if you paid the additional cost" is therefore satisfied.
Example
You play Bone Skewer and choose Nami, Headstrong from your opponent's hand.
Your opponent plays Nami to the chosen battlefield, ignoring all costs.
They declare their intention to pay the additional cost of 
.
Bone Skewer has already reduced that cost to 0, so nothing is actually paid — but because they chose to pay it, the condition is met.
Nami's triggered ability fires, stunning an enemy unit.
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